I bought 2 of these recently. The first is my main internet router and 2.4ghz wireless AP. The second is in the living room acting as a bridge from there to the office. The set-up of both was pretty simple. Asus's interface is a little too basic for my taste, but I can see how the design is intelligent for someone less technically inclined. I would like an advanced mode where the advanced menu is most of what you see, but that's severe nit picking. The traffic monitor is neat and the logging is nice.
I run 2 NAS, 1 laptop, and 1 VOIP router on the wired side. 3-5 wireless clients (laptops, phones, etc) on 2.4ghz. Across the 5 ghz bridge (~30ft away through ~2 walls) I have a Roku, TV, and satellite box connected via ethernet. On my Roku I get "HD" quality from Netflix all day every day and a very good MLB.tv picture. I don't get "true" HD streaming (ie: Amazon), obviously, but this is a vast improvement from my DIR-655 + DAP-1522 set-up. I have the 2.4ghz radio off on the far side of the bridge right now.
I'm able to run all 3 of my work VPNs across a wired connection to the main router. They are all either PPTP or SSL connections so I can't speak to any other types. Hardware NAT appears to still be enabled for me, so I suppose I'm lucky there on the VPN softwares I use.
I ran a few tests streaming Netflix across the wireless bridge while making a VOIP call. There weren't any noticeable effects to either service. Adding a BT download across one of my NASes did seem to start clogging the WAN pipe up... not the router's fault, I burst to about 30 Mbps on my current service and Netflix was using nearly all of that.
2.4ghz range is vastly improved over the DIR-655. Using Wifi Analyzer for Android on my phone I would pull about -85 dBm at the furthest point in my house (~75 ft away, 4 walls). I get about -70 dBm at that point now. In a previous dead zone (~90 ft, 5 walls, cabinetry, closet, bathroom mirror) I'm a decent -75 dBm now. Throughput likely isn't wonderful here, but a stable connection is an improvement. A potential downside is that I bet my neighbor isn't happy with my great coverage. Where my router is placed, I could probably service his whole house too.
My largest complaint is that DLink's DHCP reservation was much, much easier. I'm also, so far, underwhelmed with some of the firewall and port forwarding options. I haven't tried hooking a USB printer or disk up yet, though I'm looking forward to getting my print server off of my NAS. I'm also not a fan of the FTP port not being stealthed to the internet. If there's a way to fix this, I'd love to hear it. Everything else stealths as it should.
This new set-up has run me to the limit of my current internet connection, which I'm pretty happy with. My alternative to buying these was trying to find 2 v1 WNDR3700's, which proved fairly impossible to do. The E4200 was out at the bridging requirement. I'm not sure this router can be beat at the price point it's at right now. I know my tune may change once/if I need Asus' support.
