One of my 2 OpenVPN servers is set to Port 443 TCP, and I’ve recently got into the habit of leaving my iPhone connected to it all the time - even when I’m at home. It doesn’t seem to affect my battery life, and it doesn’t affect any aspect of my Internet activity. The real benefit is that when I leave home and use either 3G4G/public wifi, there’s no chance of my forgetting to go through my vpn.Another benefit of this is my work blocks ports to access the VPN on my home router, yet I can use the NextDNS app fine on my Pixel3.
However whenever I can I connect to my home OVPN and let Diversion do the work.